четверг, 25 августа 2011 г.

A New Therapeutic Vaccine Against Prostate Cancer

A New Therapeutic Vaccine Against Prostate Cancer.


A newly approved salutary prostate cancer vaccine won the sponsor Wednesday of a Medicare hortatory committee, increasing the chances that Medicare will be punished for the drug. Officials from Medicare, the federal indemnity program for the having one foot in the grave and disabled, will mull over the committee's desire when making a final decision on payment. Such a determination is expected in several months, the Wall Street Journal reported livfit syrup. The vaccine, called Provenge and made by the Dendreon Corp, costs $93000 per unswerving and extends survival by about four months on average, according to results from clinical trials.



A consider published in July in the New England Journal of Medicine found that the vaccine extended the lives of men with metastatic tumors wilful to exemplar hormonal treatment, compared with no treatment cydgra q drops. And the psychotherapy active less toxicity than chemotherapy.



Provenge is a restorative (not preventive) vaccine made from the patient's own bloodless blood cells. Once removed from the patient, the cells are treated with the antidepressant and placed back into the patient. These treated cells then trigger an invulnerable effect that in time kills cancer cells, leaving conventional cells unharmed.



The vaccine is given intravenously in a three-dose list delivered in two-week intervals. "The scenario of irksome to harness the safe group to close cancer has been something that masses have tried to attain for many years; this is one such strategy," swotting lead researcher Dr Philip Kantoff, a professor of nostrum at Harvard Medical School and a medical oncologist at the Dana-Farber Cancer Institute in Boston, told HealthDay.



One ace said the therapy, while far from a cure, "looks promising". Dr Elizabeth Kavaler, an urologist at Lenox Hill Hospital in New York City, said that "in this luckless classification of hormone-resistant patient, we have very petite to offer. Adding months to a man's living is better than doing nothing, especially if the curing involves smallest morbidity, as this vaccine promises".



In April, the US Food and Drug Administration approved Provenge for remedying of prostate cancer that has property to other parts of the body and is uncompliant to sample hormone treatment. For the study, Kantoff's assembly randomly assigned 512 men to endure Provenge or placebo. All of patients had advanced prostate cancer that had proven recalcitrant to recognized hormonal therapy.



On average, men receiving Provenge lived 4,1 months longer than men receiving a placebo, the researchers found. Average survival was 25,8 months for men in the Provenge group, compared with 21,7 months for men in the placebo group, message that Provenge extended survival by 22 to 25 percent, Kantoff said.



He contends that if the vaccine were utilized by men with less violent illness survival, it might be extended for even longer. "Theoretically, if you stomach race with less diseases and you inspire the untouched system, you could have a more sagacious effect, but we don't absolutely be sure that yet," he said.



Compared with other treatments, such as chemotherapy, emission and hormone therapy, Provenge has been touted as having fewer and less unyielding indirect effects. In this trial, the most stereotypical affectation things were chills, fever and headache, the researchers noted how to purchase vitaros. Commenting on the outrageous cost of Provenge, Kantoff said that "this is a care given over a four-week period, as opposed to other treatments that are given over many months, where the costs can be hilarious as well, if not comparable to or more priceless than Provenge".

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