среда, 16 ноября 2011 г.

New Blood Thinners Are Effective In Combination With Low Doses Of Aspirin

New Blood Thinners Are Effective In Combination With Low Doses Of Aspirin.

Brilinta, an experiential anti-clotting medication currently awaiting US Food and Drug Administration approval, performed better than the earnestness standard, Plavix, when old in tandem with low-dose aspirin, a unfamiliar bookwork finds anchors suma blue film. Heart patients who took Brilinta (ticagrelor) with low-dose aspirin (less than 300 milligrams) had fewer cardiovascular complications than those bewitching Plavix (clopidogrel) and low-dose aspirin, researchers found.

However, patients who took Brilinta with higher doses of aspirin (more than 300 milligrams) had worse outcomes than those who took Plavix with high-dose aspirin, the investigators reported. Antiplatelet drugs are employed to control potentially rickety blood clots from forming in patients with insightful coronary syndrome, including those who have had a callousness attack Brand Club. Brilinta has already been approved for use in many other countries.

In July 2010, an FDA panel voted 7-to-1 to commend the use of Brilinta for US patients undergoing angioplasty or stenting to unbooked blocked arteries, but the consent transform is still ongoing. The panel's praise was based in neck of the woods on previous findings from this study, called the Platelet Inhibition and Patient Outcomes (PLATO) trial.

In this example interpretation of PLATO findings, researchers found that patients who took Brilinta with low-dose aspirin were 16 percent less able than those who took Plavix with low-dose aspirin to have a essence fight or stroke, or to want within a year. The findings were reported Monday in an American Heart Association online conference.

One masterly said the inexperienced gen is valuable. "The on highlights that if one chooses to use ticagrelor in subjects with discriminating coronary syndromes, it would be practical to use aspirin 81 milligrams per broad daylight (and not 325 mg daily)," said Dr Jeffrey S Berger, helper professor of drug and chief of cardiovascular thrombosis at NYU Langone Medical Center in New York City.

And "Of note, there is particle case to ever use aspirin 325 mg exclude in the percipient milieu of a will deprecation or stroke," he added. "A higher aspirin quantity (325 mg versus 81 mg) increases the hazard of bleeding without increasing the efficacy of the drug". A memorize founder agreed that for most patients, using the dope with a lower dose of aspirin is usually warranted.

So "Patients with grave coronary syndrome have options to stave off recurrent events," study guide author Dr Kenneth W Mahaffey, co-director of cardiovascular investigation at the Duke Clinical Research Institute, and associated professor of medicament at Duke University Medical Center, said in an AHA low-down release. "Physicians choosing to use ticagrelor in countries where it is approved and handy should have regard for using a low-dose of maintenance aspirin with the drug" girls first penis. The figures and conclusions of the research should be viewed as premonitory until published in a peer-reviewed journal.

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